NKX2.8 (NKX2-8) (NM_014360) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects. [provided by RefSeq, Dec 2015]
Synonyms
Nkx2-9; NKX2.8; NKX2H
Gene ID
26257
UniProt
O15522
Accession Number mRNA
NM_014360
Chromosomal Location
14q13.3
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transcription Factors
Molecular Weight
25.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
NKX2-8
Species
Human
Protein ID
NP_055175
Overview
Recombinant protein of human NK2 homeobox 8 (NKX2-8)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/26257
Uniprot URL
https://www.uniprot.org/uniprot/O15522
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_014360
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_055175
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