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PDE4A (NM_006202) Human Recombinant Protein

Selected Variant

PH38356M5

Size: 20 µg

Product Specifications

Background

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

Overview

Recombinant protein of human phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila) (PDE4A), transcript variant 4

Synonyms

DPDE2; PDE4; PDE46

Gene ID

5141

UniProt

P27815

Accession Number mRNA

NM_006202

Chromosomal Location

19p13.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Progesterone-mediated oocyte maturation, Purine metabolism

Field of Research

Progesterone-mediated oocyte maturation, Purine metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Activity

27148684

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

72 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

PDE4A

Species

Human

Protein ID

NP_006193

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/5141

Uniprot URL

https://www.uniprot.org/uniprot/P27815

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_006202

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_006193

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