IL1 Receptor II (IL1R2) (NM_173343) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]

Overview

Recombinant protein of human interleukin 1 receptor, type II (IL1R2), transcript variant 2

Synonyms

CD121b; IL1RB; MGC47725

Gene ID

7850

UniProt

P27930

Accession Number mRNA

NM_173343

Chromosomal Location

2q11.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, MAPK signaling pathway

Field of Research

Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, MAPK signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Transmembrane

Molecular Weight

43.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.