Pirh2 (RCHY1) (NM_015436) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]

Overview

Recombinant protein of human ring finger and CHY zinc finger domain containing 1 (RCHY1), transcript variant 1

Synonyms

ARNIP; CHIMP; PIRH2; PRO1996; RNF199; ZCHY; ZNF363

Gene ID

25898

UniProt

Q96PM5

Accession Number mRNA

NM_015436

Chromosomal Location

4q21.1

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

P53 signaling pathway, Ubiquitin mediated proteolysis

Field of Research

P53 signaling pathway, Ubiquitin mediated proteolysis

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Stem cell - Pluripotency

Molecular Weight

29.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.