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HMGCS2 (NM_005518) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Synonyms

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) ; hydroxymethylglutaryl-CoA synthase 2; OTTHUMP00000013928

Gene ID

3158

UniProt

P54868, A0A140VJL2

Accession Number mRNA

NM_005518

Chromosomal Location

1p12

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Butanoate metabolism, Metabolic pathways, PPAR signaling pathway, Synthesis and degradation of ketone bodies, Terpenoid backbone biosynthesis, Valine, leucine and isoleucine degradation

Field of Research

Butanoate metabolism, Metabolic pathways, PPAR signaling pathway, Synthesis and degradation of ketone bodies, Terpenoid backbone biosynthesis, Valine, leucine and isoleucine degradation

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

52.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

HMGCS2

Species

Human

Protein ID

NP_005509

Overview

Recombinant protein of human 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) (HMGCS2), nuclear gene encoding mitochondrial protein

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/3158

Uniprot URL

https://www.uniprot.org/uniprot/P54868

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_005518

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_005509

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