GUCY1B1 (NM_000857) Human Recombinant Protein

Product Specifications

Background

This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate) . The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Overview

Recombinant protein of human guanylate cyclase 1, soluble, beta 3 (GUCY1B3)

Synonyms

GC-S-beta-1; GC-SB3; GUC1B3; GUCB3; GUCSB3; GUCY1B3

Gene ID

2983

UniProt

Q02153

Accession Number mRNA

NM_000857

Chromosomal Location

4q32.1

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Gap junction, Long-term depression, Purine metabolism, Vascular smooth muscle contraction

Field of Research

Gap junction, Long-term depression, Purine metabolism, Vascular smooth muscle contraction

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

70.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.