Semaphorin 4D (SEMA4D) (NM_006378) Human Recombinant Protein

Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282) . Regulates GABAergic synapse development (By similarity) . Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity) . Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569) . Promotes the migration of cerebellar granule cells (PubMed:16055703) . Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214) . Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703) .[UniProtKB/Swiss-Prot Function]

Recombinant protein of human sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D (SEMA4D), transcript variant 1

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.