Semaphorin 4D (SEMA4D) (NM_006378) Human Recombinant Protein
Product Specifications
Background
Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282) . Regulates GABAergic synapse development (By similarity) . Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity) . Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569) . Promotes the migration of cerebellar granule cells (PubMed:16055703) . Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214) . Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703) .[UniProtKB/Swiss-Prot Function]
Synonyms
A8; BB18; C9orf164; CD100; coll-4; COLL4; GR3; M-sema-G; SEMAJ
Gene ID
10507
UniProt
Q92854
Accession Number mRNA
NM_006378
Chromosomal Location
9q22.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Axon guidance
Field of Research
Axon guidance
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
96 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SEMA4D
Species
Human
Protein ID
NP_006369
Overview
Recombinant protein of human sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D (SEMA4D), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/10507
Uniprot URL
https://www.uniprot.org/uniprot/Q92854
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_006378
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_006369
Curated Selection
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