SIGLEC8 (NM_014442) Human Recombinant Protein
Product Specifications
Background
Sialic acid-binding immunoglobulin (Ig) -like lectins, or SIGLECs (e.g., CD33 (MIM 159590) ), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]) .[supplied by OMIM, May 2010]
Synonyms
SAF2; SIGLEC-8; SIGLEC8L
Gene ID
27181
UniProt
Q9NYZ4
Accession Number mRNA
NM_014442
Chromosomal Location
19q13.41
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
53.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SIGLEC8
Species
Human
Protein ID
NP_055257
Overview
Recombinant protein of human sialic acid binding Ig-like lectin 8 (SIGLEC8)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/27181
Uniprot URL
https://www.uniprot.org/uniprot/Q9NYZ4
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_014442
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_055257
Curated Selection
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