STAT2 (NM_005419) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. The protein mediates innate antiviral activity. Mutations in this gene result in Immunodeficiency 44. [provided by RefSeq, Aug 2020]

Overview

Recombinant protein of human signal transducer and activator of transcription 2, 113kDa (STAT2)

Synonyms

IMD44; ISGF-3; P113; PTORCH3; STAT113

Gene ID

6773

UniProt

P52630, R9QE65

Accession Number mRNA

NM_005419

Chromosomal Location

12q13.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Chemokine signaling pathway, Jak-STAT signaling pathway

Field of Research

Chemokine signaling pathway, Jak-STAT signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Transcription Factors

Molecular Weight

97.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.