STAT2 (NM_005419) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. The protein mediates innate antiviral activity. Mutations in this gene result in Immunodeficiency 44. [provided by RefSeq, Aug 2020]
Overview
Recombinant protein of human signal transducer and activator of transcription 2, 113kDa (STAT2)
Synonyms
IMD44; ISGF-3; P113; PTORCH3; STAT113
Gene ID
6773
UniProt
P52630, R9QE65
Accession Number mRNA
NM_005419
Chromosomal Location
12q13.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Chemokine signaling pathway, Jak-STAT signaling pathway
Field of Research
Chemokine signaling pathway, Jak-STAT signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transcription Factors
Molecular Weight
97.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
STAT2
Species
Human
Protein ID
NP_005410
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/6773
Uniprot URL
https://www.uniprot.org/uniprot/P52630
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005419
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005410
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