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14-3-3 theta (YWHAQ) (NM_006826) Human Recombinant Protein

Product Specifications

Background

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]

Synonyms

1C5; 14-3-3; HS1

Gene ID

10971

UniProt

P27348

Accession Number mRNA

NM_006826

Chromosomal Location

2p25.1

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Cell cycle, Neurotrophin signaling pathway, Oocyte meiosis, Pathogenic Escherichia coli infection

Field of Research

Cell cycle, Neurotrophin signaling pathway, Oocyte meiosis, Pathogenic Escherichia coli infection

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

27.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

YWHAQ

Species

Human

Protein ID

NP_006817

Overview

Recombinant protein of human tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide (YWHAQ)

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/10971

Uniprot URL

https://www.uniprot.org/uniprot/P27348

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_006826

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_006817

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