UBE2L3 (NM_003347) Human Recombinant Protein
Product Specifications
Background
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) . This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
Synonyms
E2-F1; L-UBC; UBCH7; UbcM4
Gene ID
7332
UniProt
P68036, A0A024R1A4
Accession Number mRNA
NM_003347
Chromosomal Location
22q11.21
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Parkinson's disease, Ubiquitin mediated proteolysis
Field of Research
Parkinson's disease, Ubiquitin mediated proteolysis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Activity
26616590
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
17.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
UBE2L3
Species
Human
Protein ID
NP_003338
Overview
Recombinant protein of human ubiquitin-conjugating enzyme E2L 3 (UBE2L3), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/7332
Uniprot URL
https://www.uniprot.org/uniprot/P68036
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_003347
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_003338
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