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ZAP70 (NM_001079) Human Recombinant Protein

Selected Variant

PH37911M5

Size: 20 µg

Product Specifications

Background

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human zeta-chain (TCR) associated protein kinase 70kDa (ZAP70), transcript variant 1

Synonyms

ADMIO2; IMD48; SRK; STCD; STD; TZK; ZAP-70

Gene ID

7535

UniProt

P43403

Accession Number mRNA

NM_001079

Chromosomal Location

2q11.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Natural killer cell mediated cytotoxicity, Primary immunodeficiency, T cell receptor signaling pathway

Field of Research

Natural killer cell mediated cytotoxicity, Primary immunodeficiency, T cell receptor signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Protein Kinase

Molecular Weight

69.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

ZAP70

Species

Human

Protein ID

NP_001070

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/7535

Uniprot URL

https://www.uniprot.org/uniprot/P43403

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001079

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001070

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