ICOS Ligand (ICOSLG) (NM_015259) Human Recombinant Protein
Product Specifications
Background
Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity) .[UniProtKB/Swiss-Prot Function]
Overview
Recombinant protein of human inducible T-cell co-stimulator ligand (ICOSLG)
Synonyms
B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275; GL50; ICOS-L; ICOSL; LICOS
Gene ID
23308
UniProt
O75144, A0N0L8
Accession Number mRNA
NM_015259
Chromosomal Location
21q22.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Cell adhesion molecules (CAMs)
Field of Research
Cell adhesion molecules (CAMs)
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Transmembrane
Molecular Weight
33.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ICOSLG
Species
Human
Protein ID
NP_056074
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/23308
Uniprot URL
https://www.uniprot.org/uniprot/O75144
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_015259
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_056074
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