KREMEN1 (NM_001039571) Human Recombinant Protein
Product Specifications
Background
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT) /beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6) . It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]
Synonyms
FLJ31863; KREMEM1; KREMEN; kringle-coding gene marking the eye and the nose; kringle-containing transmembrane protein 1; kringle containing transmembrane protein 1; KRM1; OTTHUMP00000028977
Gene ID
83999
UniProt
Q96MU8
Accession Number mRNA
NM_001039571
Chromosomal Location
22q12.1
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
48.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
KREMEN1
Species
Human
Protein ID
NP_001034660
Overview
Recombinant protein of human kringle containing transmembrane protein 1 (KREMEN1), transcript variant 4
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/83999
Uniprot URL
https://www.uniprot.org/uniprot/Q96MU8
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001039571
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001034660
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