ORC6L (ORC6) (NM_014321) Human Recombinant Protein
Product Specifications
Background
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]
Synonyms
ORC6L
Gene ID
23594
UniProt
Q9Y5N6, A0A024R6R3
Accession Number mRNA
NM_014321
Chromosomal Location
16q11.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Cell cycle
Field of Research
Cell cycle
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Stem cell - Pluripotency
Molecular Weight
27.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ORC6
Species
Human
Protein ID
NP_055136
Overview
Recombinant protein of human origin recognition complex, subunit 6 like (yeast) (ORC6L)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/23594
Uniprot URL
https://www.uniprot.org/uniprot/Q9Y5N6
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_014321
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_055136
Curated Selection
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