ORC6L (ORC6) (NM_014321) Human Recombinant Protein

Product Specifications

Background

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]

Overview

Recombinant protein of human origin recognition complex, subunit 6 like (yeast) (ORC6L)

Synonyms

ORC6L

Gene ID

23594

UniProt

Q9Y5N6, A0A024R6R3

Accession Number mRNA

NM_014321

Chromosomal Location

16q11.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Cell cycle

Field of Research

Cell cycle

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Stem cell - Pluripotency

Molecular Weight

27.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.