AKR1C2 (NM_205845) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Synonyms
AKR1C-pseudo; BABP; DD; DD-2; DD/BABP; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8; TDD
Gene ID
1646
UniProt
P52895
Accession Number mRNA
NM_205845
Chromosomal Location
10p15.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Metabolism of xenobiotics by cytochrome P450
Field of Research
Metabolism of xenobiotics by cytochrome P450
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
36.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
AKR1C2
Species
Human
Protein ID
NP_995317
Overview
Recombinant protein of human aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) (AKR1C2), transcript variant 2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/1646
Uniprot URL
https://www.uniprot.org/uniprot/P52895
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_205845
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_995317
Curated Selection
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