CRTR1 (TFCP2L1) (NM_014553) Human Recombinant Protein

Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs) (PubMed:25215486, PubMed:26906118) . With KLF2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling (By similarity) . Required for normal duct development in the salivary gland and kidney (By similarity) . Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively (By similarity) . Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, OXGR1, CA12, SLC4A1, AQP6 and IC-specific transcription factor FOXI1 (By similarity) . Regulates also the expression of JAG1 and subsequent notch signaling in the collecting duct (By similarity) . JAG1 initiates notch signaling in PCs but inhibits notch signaling in ICs (By similarity) . Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (By similarity) . Modulates the placental expression of CYP11A1 (PubMed:10644752) .[UniProtKB/Swiss-Prot Function]

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.