IRAKM (IRAK3) (NM_007199) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Synonyms
ASRT5; IRAKM
Gene ID
11213
UniProt
Q9Y616
Accession Number mRNA
NM_007199
Chromosomal Location
12q14.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Apoptosis, Neurotrophin signaling pathway
Field of Research
Apoptosis, Neurotrophin signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Protein Kinase
Molecular Weight
67.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
IRAK3
Species
Human
Protein ID
NP_009130
Overview
Recombinant protein of human interleukin-1 receptor-associated kinase 3 (IRAK3), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/11213
Uniprot URL
https://www.uniprot.org/uniprot/Q9Y616
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_007199
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_009130
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