IRAKM (IRAK3) (NM_007199) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Overview

Recombinant protein of human interleukin-1 receptor-associated kinase 3 (IRAK3), transcript variant 1

Synonyms

ASRT5; IRAKM

Gene ID

11213

UniProt

Q9Y616

Accession Number mRNA

NM_007199

Chromosomal Location

12q14.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Apoptosis, Neurotrophin signaling pathway

Field of Research

Apoptosis, Neurotrophin signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Protein Kinase

Molecular Weight

67.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.