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SOCS3 (NM_003955) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN) -gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]

Synonyms

ATOD4; CIS3; Cish3; SOCS-3; SSI-3; SSI3

Gene ID

9021

UniProt

O14543, Q6FI39

Accession Number mRNA

NM_003955

Chromosomal Location

17q25.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Adipocytokine signaling pathway, Insulin signaling pathway, Jak-STAT signaling pathway, Type II diabetes mellitus, Ubiquitin mediated proteolysis

Field of Research

Adipocytokine signaling pathway, Insulin signaling pathway, Jak-STAT signaling pathway, Type II diabetes mellitus, Ubiquitin mediated proteolysis

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

24.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

SOCS3

Species

Human

Protein ID

NP_003946

Overview

Recombinant protein of human suppressor of cytokine signaling 3 (SOCS3)

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/9021

Uniprot URL

https://www.uniprot.org/uniprot/O14543

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_003955

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_003946

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