NOTUM (NM_178493) Human Recombinant Protein
Product Specifications
Background
Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175) .[UniProtKB/Swiss-Prot Function]
Overview
Recombinant protein of human notum pectinacetylesterase homolog (Drosophila) (NOTUM)
Synonyms
HNOTUM
Gene ID
147111
UniProt
Q6P988
Accession Number mRNA
NM_178493
Chromosomal Location
17q25.3
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Activity
29719227
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
48.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
NOTUM
Species
Human
Protein ID
NP_848588
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/147111
Uniprot URL
https://www.uniprot.org/uniprot/Q6P988
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_178493
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_848588
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