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LDHA (NM_005566) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008]

Synonyms

GSD11; HEL-S-133P; LDHM; PIG19

Gene ID

3939

UniProt

P00338, V9HWB9

Accession Number mRNA

NM_005566

Chromosomal Location

11p15.1

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Cysteine and methionine metabolism, Glycolysis / Gluconeogenesis, Metabolic pathways, Propanoate metabolism, Pyruvate metabolism

Field of Research

Cysteine and methionine metabolism, Glycolysis / Gluconeogenesis, Metabolic pathways, Propanoate metabolism, Pyruvate metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Activity

Higher specific activity than endogenous human LDHA: Leading Biology human recombinant LDHA was compared side-by-side with purified human liver LDH5 in a spectrophotometric pyruvate to lactate conversion assay. Activity is shown as a decrease in absorbance at 340nm over time. The activity of recombinant human LDHA is comparable to that of endogenously expressed human LDH5.

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

36.5 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

LDHA

Species

Human

Protein ID

NP_005557

Overview

Recombinant protein of human lactate dehydrogenase A (LDHA), transcript variant 1

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/3939

Uniprot URL

https://www.uniprot.org/uniprot/P00338

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_005566

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_005557

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