NKIRAS2 (NM_017595) Human Recombinant Protein
Product Specifications
Background
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity) .[UniProtKB/Swiss-Prot Function]
Synonyms
KappaB-Ras2; KBRAS2
Gene ID
28511
UniProt
Q9NYR9, A0A024R1Z4
Accession Number mRNA
NM_017595
Chromosomal Location
17q21.2
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
21.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
NKIRAS2
Species
Human
Protein ID
NP_060065
Overview
Recombinant protein of human NFKB inhibitor interacting Ras-like 2 (NKIRAS2), transcript variant 2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/28511
Uniprot URL
https://www.uniprot.org/uniprot/Q9NYR9
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_017595
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_060065
Curated Selection
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