WWP2 (NM_199424) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. [provided by RefSeq, Jul 2012]
Synonyms
AIP2; WWp2-like
Gene ID
11060
UniProt
O00308, B4DHF6
Accession Number mRNA
NM_199424
Chromosomal Location
16q22.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Ubiquitin mediated proteolysis
Field of Research
Ubiquitin mediated proteolysis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
50.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
WWP2
Species
Human
Protein ID
NP_955456
Overview
Recombinant protein of human WW domain containing E3 ubiquitin protein ligase 2 (WWP2), transcript variant 2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/11060
Uniprot URL
https://www.uniprot.org/uniprot/O00308
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_199424
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_955456
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