DNA Primase (PRIM2) (NM_000947) Human Recombinant Protein
Product Specifications
Background
This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a DNA-directed RNA polymerase to synthesize small RNA primers that are used to create Okazaki fragments on the lagging strand of the DNA. Alternative splicing of this gene results in multiple transcript variants. This gene has a related pseudogene, which is also present on chromosome 6. [provided by RefSeq, Apr 2014]
Overview
Recombinant protein of human primase, DNA, polypeptide 2 (58kDa) (PRIM2)
Synonyms
P58; PRIM2A
Gene ID
5558
UniProt
P49643
Accession Number mRNA
NM_000947
Chromosomal Location
6p11.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
DNA replication, Metabolic pathways, Purine metabolism, Pyrimidine metabolism
Field of Research
DNA replication, Metabolic pathways, Purine metabolism, Pyrimidine metabolism
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
58.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PRIM2
Species
Human
Protein ID
NP_000938
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5558
Uniprot URL
https://www.uniprot.org/uniprot/P49643
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000947
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000938
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