DNase II (DNASE2) (NM_001375) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human deoxyribonuclease II, lysosomal (DNASE2)

Synonyms

DNASE2A; DNL; DNL2

Gene ID

1777

UniProt

O00115, A0A024R7F4

Accession Number mRNA

NM_001375

Chromosomal Location

19p13.13

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Lysosome

Field of Research

Lysosome

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

39.4 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.