DNase II (DNASE2) (NM_001375) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. [provided by RefSeq, Jul 2008]
Synonyms
DNASE2A; DNL; DNL2
Gene ID
1777
UniProt
O00115, A0A024R7F4
Accession Number mRNA
NM_001375
Chromosomal Location
19p13.13
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Lysosome
Field of Research
Lysosome
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
39.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
DNASE2
Species
Human
Protein ID
NP_001366
Overview
Recombinant protein of human deoxyribonuclease II, lysosomal (DNASE2)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/1777
Uniprot URL
https://www.uniprot.org/uniprot/O00115
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001375
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001366
Curated Selection
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