HMBOX1 (NM_024567) Human Recombinant Protein

Product Specifications

Background

Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (PubMed:23813958, PubMed:23685356) . Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (PubMed:23685356) . Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity) . Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (PubMed:23813958) . Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (PubMed:23813958) . Might also be involved in the DNA damage response at telomeres (PubMed:23813958) .[UniProtKB/Swiss-Prot Function]

Overview

Recombinant protein of human homeobox containing 1 (HMBOX1), transcript variant 1

Synonyms

HNF1LA; HOT1; PBHNF; TAH1

Gene ID

79618

UniProt

Q6NT76

Accession Number mRNA

NM_024567

Chromosomal Location

8p21.1-p12

Expression System

HEK293T

Tag

C-Myc/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Transcription Factors

Molecular Weight

47.1 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.