HMBOX1 (NM_024567) Human Recombinant Protein

Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (PubMed:23813958, PubMed:23685356) . Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (PubMed:23685356) . Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity) . Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (PubMed:23813958) . Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (PubMed:23813958) . Might also be involved in the DNA damage response at telomeres (PubMed:23813958) .[UniProtKB/Swiss-Prot Function]

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.