IL7R alpha (IL7R) (NM_002185) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a receptor for interleukin 7 (IL7) . The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V (D) J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID) . Alternatively spliced transcript variants have been found. [provided by RefSeq, Dec 2015]

Overview

Recombinant protein of human interleukin 7 receptor (IL7R)

Synonyms

CD127; CDW127; IL-7R-alpha; IL7RA; ILRA

Gene ID

3575

UniProt

P16871

Accession Number mRNA

NM_002185

Chromosomal Location

5p13.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway, Primary immunodeficiency

Field of Research

Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway, Primary immunodeficiency

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, ES Cell Differentiation/IPS, Transmembrane

Molecular Weight

49.4 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.