TPK1 (NM_022445) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene functions as a homodimer and catalyzes the conversion of thiamine to thiamine pyrophosphate, a cofactor for some enzymes of the glycolytic and energy production pathways. Defects in this gene are a cause of thiamine metabolism dysfunction syndrome-5. [provided by RefSeq, Apr 2017]

Overview

Recombinant protein of human thiamin pyrophosphokinase 1 (TPK1), transcript variant 1

Synonyms

HTPK1; PP20; THMD5

Gene ID

27010

UniProt

Q9H3S4, A0A090N8Y0

Accession Number mRNA

NM_022445

Chromosomal Location

7q35

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Metabolic pathways, Thiamine metabolism

Field of Research

Metabolic pathways, Thiamine metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

27.1 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.