TPK1 (NM_022445) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene functions as a homodimer and catalyzes the conversion of thiamine to thiamine pyrophosphate, a cofactor for some enzymes of the glycolytic and energy production pathways. Defects in this gene are a cause of thiamine metabolism dysfunction syndrome-5. [provided by RefSeq, Apr 2017]
Overview
Recombinant protein of human thiamin pyrophosphokinase 1 (TPK1), transcript variant 1
Synonyms
HTPK1; PP20; THMD5
Gene ID
27010
UniProt
Q9H3S4, A0A090N8Y0
Accession Number mRNA
NM_022445
Chromosomal Location
7q35
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Metabolic pathways, Thiamine metabolism
Field of Research
Metabolic pathways, Thiamine metabolism
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
27.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TPK1
Species
Human
Protein ID
NP_071890
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/27010
Uniprot URL
https://www.uniprot.org/uniprot/Q9H3S4
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_022445
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_071890
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