LOK (STK10) (NM_005990) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008]
Synonyms
LOK; PRO2729
Gene ID
6793
UniProt
O94804
Accession Number mRNA
NM_005990
Chromosomal Location
5q35.1
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Protein Kinase
Molecular Weight
112 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
STK10
Species
Human
Protein ID
NP_005981
Overview
Recombinant protein of human serine/threonine kinase 10 (STK10)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/6793
Uniprot URL
https://www.uniprot.org/uniprot/O94804
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005990
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005981
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