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Ferritin Heavy Chain (FTH1) (NM_002032) Human Recombinant Protein

Product Specifications

Background

This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human ferritin, heavy polypeptide 1 (FTH1)

Synonyms

FHC; FTH; FTHL6; HFE5; PIG15; PLIF

Gene ID

2495

UniProt

P02794, A0A024R525

Accession Number mRNA

NM_002032

Chromosomal Location

11q12.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Porphyrin and chlorophyll metabolism

Field of Research

Porphyrin and chlorophyll metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

21 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

FTH1

Species

Human

Protein ID

NP_002023

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/2495

Uniprot URL

https://www.uniprot.org/uniprot/P02794

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_002032

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_002023

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