AGL (NM_000642) Human Recombinant Protein
Product Specifications
Background
This gene encodes the glycogen debrancher enzyme which is involved in glycogen degradation. This enzyme has two independent catalytic activities which occur at different sites on the protein: a 4-alpha-glucotransferase activity and a amylo-1,6-glucosidase activity. Mutations in this gene are associated with glycogen storage disease although a wide range of enzymatic and clinical variability occurs which may be due to tissue-specific alternative splicing. Alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human amylo-1, 6-glucosidase, 4-alpha-glucanotransferase (AGL), transcript variant 1
Synonyms
GDE
Gene ID
178
UniProt
P35573, A0A0S2A4E4
Accession Number mRNA
NM_000642
Chromosomal Location
1p21.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Metabolic pathways, Starch and sucrose metabolism
Field of Research
Metabolic pathways, Starch and sucrose metabolism
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
174.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
AGL
Species
Human
Protein ID
NP_000633
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/178
Uniprot URL
https://www.uniprot.org/uniprot/P35573
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000642
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000633
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