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PDE6H (NM_006205) Human Recombinant Protein

Product Specifications

Background

This gene encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma) . It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A) . [provided by RefSeq, Mar 2010]

Overview

Recombinant protein of human phosphodiesterase 6H, cGMP-specific, cone, gamma (PDE6H)

Synonyms

ACHM6; RCD3

Gene ID

5149

UniProt

Q13956

Accession Number mRNA

NM_006205

Chromosomal Location

12p12.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Progesterone-mediated oocyte maturation, Purine metabolism

Field of Research

Progesterone-mediated oocyte maturation, Purine metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

8.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

PDE6H

Species

Human

Protein ID

NP_006196

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/5149

Uniprot URL

https://www.uniprot.org/uniprot/Q13956

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_006205

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_006196

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