PDE6H (NM_006205) Human Recombinant Protein
Product Specifications
Background
This gene encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma) . It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A) . [provided by RefSeq, Mar 2010]
Overview
Recombinant protein of human phosphodiesterase 6H, cGMP-specific, cone, gamma (PDE6H)
Synonyms
ACHM6; RCD3
Gene ID
5149
UniProt
Q13956
Accession Number mRNA
NM_006205
Chromosomal Location
12p12.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Progesterone-mediated oocyte maturation, Purine metabolism
Field of Research
Progesterone-mediated oocyte maturation, Purine metabolism
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
8.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PDE6H
Species
Human
Protein ID
NP_006196
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5149
Uniprot URL
https://www.uniprot.org/uniprot/Q13956
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_006205
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_006196
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