MARCKS (NM_002356) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human myristoylated alanine-rich protein kinase C substrate (MARCKS)
Synonyms
80K-L; MACS; PKCSL; PRKCSL
Gene ID
4082
UniProt
P29966, Q6NVI1
Accession Number mRNA
NM_002356
Chromosomal Location
6q21
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Fc gamma R-mediated phagocytosis
Field of Research
Fc gamma R-mediated phagocytosis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Activity
25863174
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
31.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
MARCKS
Species
Human
Protein ID
NP_002347
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4082
Uniprot URL
https://www.uniprot.org/uniprot/P29966
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_002356
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_002347
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