PI 3 Kinase regulatory subunit 4 (PIK3R4) (NM_014602) Human Recombinant Protein
Product Specifications
Background
Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123) .[UniProtKB/Swiss-Prot Function]
Synonyms
P150; VPS15
Gene ID
30849
UniProt
Q99570
Accession Number mRNA
NM_014602
Chromosomal Location
3q22.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Regulation of autophagy
Field of Research
Regulation of autophagy
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Protein Kinase
Molecular Weight
152.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PIK3R4
Species
Human
Protein ID
NP_055417
Overview
Recombinant protein of human phosphoinositide-3-kinase, regulatory subunit 4 (PIK3R4)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/30849
Uniprot URL
https://www.uniprot.org/uniprot/Q99570
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_014602
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_055417
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