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Retinoid X Receptor alpha (RXRA) (NM_002957) Human Recombinant Protein

Product Specifications

Background

Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]

Overview

Recombinant protein of human retinoid X receptor, alpha (RXRA)

Synonyms

NR2B1

Gene ID

6256

UniProt

P19793, F1D8Q5, Q6P3U7

Accession Number mRNA

NM_002957

Chromosomal Location

9q34.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Adipocytokine signaling pathway, Non-small cell lung cancer, Pathways in cancer, PPAR signaling pathway, Small cell lung cancer, Thyroid cancer

Field of Research

Adipocytokine signaling pathway, Non-small cell lung cancer, Pathways in cancer, PPAR signaling pathway, Small cell lung cancer, Thyroid cancer

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Nuclear Hormone Receptor, Transcription Factors

Molecular Weight

50.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

RXRA

Species

Human

Protein ID

NP_002948

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/6256

Uniprot URL

https://www.uniprot.org/uniprot/P19793

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_002957

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_002948

Frequently Asked Questions

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