PD1 (PDCD1) (NM_005018) Human Recombinant Protein
Product Specifications
Background
Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020]
Overview
Recombinant protein of human programmed cell death 1 (PDCD1)
Synonyms
CD279; hPD-1; hPD-l; hSLE1; PD-1; PD1; SLEB2
Gene ID
5133
UniProt
Q15116, A0A0M3M0G7
Accession Number mRNA
NM_005018
Chromosomal Location
2q37.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Cell adhesion molecules (CAMs), T cell receptor signaling pathway
Field of Research
Cell adhesion molecules (CAMs), T cell receptor signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
29.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PDCD1
Species
Human
Protein ID
NP_005009
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5133
Uniprot URL
https://www.uniprot.org/uniprot/Q15116
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005018
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005009
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