Proteinase Activated Receptor 4 (F2RL3) (NM_003950) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung cancer in human patients. [provided by RefSeq, Sep 2016]

Overview

Recombinant protein of human coagulation factor II (thrombin) receptor-like 3 (F2RL3)

Synonyms

PAR4

Gene ID

9002

UniProt

Q96RI0

Accession Number mRNA

NM_003950

Chromosomal Location

19p13.11

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Neuroactive ligand-receptor interaction

Field of Research

Neuroactive ligand-receptor interaction

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, GPCR, Transmembrane

Molecular Weight

36.2 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.