Steroid sulfatase (STS) (NM_000351) Human Recombinant Protein
Product Specifications
Background
This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI) . Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726) . [provided by RefSeq, Mar 2016]
Overview
Recombinant protein of human steroid sulfatase (microsomal), isozyme S (STS)
Synonyms
ARSC; ARSC1; ASC; ES; SSDD; XLI
Gene ID
412
UniProt
P08842
Accession Number mRNA
NM_000351
Chromosomal Location
Xp22.31
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Androgen and estrogen metabolism
Field of Research
Androgen and estrogen metabolism
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
62.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
STS
Species
Human
Protein ID
NP_000342
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/412
Uniprot URL
https://www.uniprot.org/uniprot/P08842
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000351
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000342
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