MC2 receptor (MC2R) (NM_000529) Human Recombinant Protein
Product Specifications
Background
MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC) . MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014]
Synonyms
ACTHR
Gene ID
4158
UniProt
Q01718
Accession Number mRNA
NM_000529
Chromosomal Location
18p11.21
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Neuroactive ligand-receptor interaction
Field of Research
Neuroactive ligand-receptor interaction
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, GPCR, Transmembrane
Molecular Weight
33.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
MC2R
Species
Human
Protein ID
NP_000520
Overview
Recombinant protein of human melanocortin 2 receptor (adrenocorticotropic hormone) (MC2R)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4158
Uniprot URL
https://www.uniprot.org/uniprot/Q01718
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000529
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000520
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