ATG5 (NM_004849) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Several transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Overview
Recombinant protein of human ATG5 autophagy related 5 homolog (S. cerevisiae) (ATG5)
Synonyms
APG5; APG5-LIKE; APG5L; ASP; hAPG5; SCAR25
Gene ID
9474
UniProt
Q9H1Y0, Q7Z3H3, A9UGY9
Accession Number mRNA
NM_004849
Chromosomal Location
6q21
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Regulation of autophagy, RIG-I-like receptor signaling pathway
Field of Research
Regulation of autophagy, RIG-I-like receptor signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
32.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ATG5
Species
Human
Protein ID
NP_004840
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/9474
Uniprot URL
https://www.uniprot.org/uniprot/Q9H1Y0
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004849
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004840
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