NIPP1 (PPP1R8) (NM_138558) Human Recombinant Protein
Product Specifications
Background
This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008]
Synonyms
ARD-1; ARD1; NIPP-1; NIPP1; PRO2047
Gene ID
5511
UniProt
Q12972
Accession Number mRNA
NM_138558
Chromosomal Location
1p35.3
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transcription Factors
Molecular Weight
22.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PPP1R8
Species
Human
Protein ID
NP_612568
Overview
Recombinant protein of human protein phosphatase 1, regulatory (inhibitor) subunit 8 (PPP1R8), transcript variant 2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5511
Uniprot URL
https://www.uniprot.org/uniprot/Q12972
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_138558
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_612568
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