Osteopontin (SPP1) (NM_001040060) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Overview
Purified recombinant protein of human secreted phosphoprotein 1 (SPP1), transcript variant 3, with C-terminal MYC/DDK tag, secretory expressed in HEK293 cells, 20ug
Synonyms
BNSP; BSPI; ETA-1; OPN
Gene ID
6696
UniProt
P10451, A0A024RDJ0
Accession Number mRNA
NM_001040060
Chromosomal Location
4q22.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
ECM-receptor interaction, Focal adhesion, Toll-like receptor signaling pathway
Field of Research
ECM-receptor interaction, Focal adhesion, Toll-like receptor signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Activity
29959420
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Secreted Protein
Molecular Weight
30.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SPP1
Species
Human
Protein ID
NP_001035149
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/6696
Uniprot URL
https://www.uniprot.org/uniprot/P10451
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001040060
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001035149
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