MST1 (STK4) (NM_006282) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
Synonyms
KRS2; MST1; TIIAC; YSK3
Gene ID
6789
UniProt
Q13043
Accession Number mRNA
NM_006282
Chromosomal Location
20q13.12
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
MAPK signaling pathway, Non-small cell lung cancer, Pathways in cancer
Field of Research
MAPK signaling pathway, Non-small cell lung cancer, Pathways in cancer
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Protein Kinase
Molecular Weight
55.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
STK4
Species
Human
Protein ID
NP_006273
Overview
Recombinant protein of human serine/threonine kinase 4 (STK4)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/6789
Uniprot URL
https://www.uniprot.org/uniprot/Q13043
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_006282
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_006273
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