EP4 (PTGER4) (NM_000958) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2) . This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
Synonyms
EP4; EP4R
Gene ID
5734
UniProt
P35408, A0PJF5
Accession Number mRNA
NM_000958
Chromosomal Location
5p13.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Neuroactive ligand-receptor interaction
Field of Research
Neuroactive ligand-receptor interaction
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, GPCR, Transmembrane
Molecular Weight
52.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PTGER4
Species
Human
Protein ID
NP_000949
Overview
Recombinant protein of human prostaglandin E receptor 4 (subtype EP4) (PTGER4)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5734
Uniprot URL
https://www.uniprot.org/uniprot/P35408
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000958
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000949
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