Tyrosine Hydroxylase (TH) (NM_000360) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human tyrosine hydroxylase (TH), transcript variant 2

Synonyms

DYT5b; DYT14; TYH

Gene ID

7054

UniProt

P07101

Accession Number mRNA

NM_000360

Chromosomal Location

11p15.5

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Metabolic pathways, Parkinson's disease, Tyrosine metabolism

Field of Research

Metabolic pathways, Parkinson's disease, Tyrosine metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

55.4 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.