TNFRSF4 (NM_003327) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
Synonyms
ACT35; CD134; IMD16; OX40; TXGP1L
Gene ID
7293
UniProt
P43489
Accession Number mRNA
NM_003327
Chromosomal Location
1p36.33
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Cytokine-cytokine receptor interaction
Field of Research
Cytokine-cytokine receptor interaction
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Transmembrane
Molecular Weight
26.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TNFRSF4
Species
Human
Protein ID
NP_003318
Overview
Recombinant protein of human tumor necrosis factor receptor superfamily, member 4 (TNFRSF4)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/7293
Uniprot URL
https://www.uniprot.org/uniprot/P43489
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_003327
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_003318
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