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VARS2 (NM_020442) Human Recombinant Protein

Product Specifications

Background

This gene encodes a mitochondrial aminoacyl-tRNA synthetase, which catalyzes the attachment of valine to tRNA (Val) for mitochondrial translation. Mutations in this gene cause combined oxidative phosphorylation deficiency-20, and are also associated with early-onset mitochondrial encephalopathies. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2014]

Synonyms

COXPD20; VALRS; VARS2L; VARSL

Gene ID

57176

UniProt

Q5ST30, B4E0K6, B4DG77

Accession Number mRNA

NM_020442

Chromosomal Location

6p21.33

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Aminoacyl-tRNA biosynthesis, Valine, leucine and isoleucine biosynthesis

Field of Research

Aminoacyl-tRNA biosynthesis, Valine, leucine and isoleucine biosynthesis

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Transcription Factors

Molecular Weight

118.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

VARS2

Species

Human

Protein ID

NP_065175

Overview

Recombinant protein of human valyl-tRNA synthetase 2, mitochondrial (putative) (VARS2), nuclear gene encoding mitochondrial protein

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/57176

Uniprot URL

https://www.uniprot.org/uniprot/Q5ST30

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_020442

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_065175

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